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Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study
BACKGROUND/OBJECTIVE: Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the associ...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928780/ https://www.ncbi.nlm.nih.gov/pubmed/29740354 http://dx.doi.org/10.3389/fpsyt.2018.00133 |
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author | Tzeng, Nian-Sheng Chang, Hsin-An Chung, Chi-Hsiang Kao, Yu-Chen Chang, Chuan-Chia Yeh, Hui-Wen Chiang, Wei-Shan Chou, Yu-Ching Chang, Shan-Yueh Chien, Wu-Chien |
author_facet | Tzeng, Nian-Sheng Chang, Hsin-An Chung, Chi-Hsiang Kao, Yu-Chen Chang, Chuan-Chia Yeh, Hui-Wen Chiang, Wei-Shan Chou, Yu-Ching Chang, Shan-Yueh Chien, Wu-Chien |
author_sort | Tzeng, Nian-Sheng |
collection | PubMed |
description | BACKGROUND/OBJECTIVE: Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan. METHODS: This cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000–2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray’s competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up. RESULTS: Of the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (p < 0.001). Fine and Gray’s competing risk model analysis revealed that the adjusted HR was 1.659 (95% CI = 1.602–1.717, p < 0.001). In this study, we found that the groups of atopic dermatitis alone and the allergic rhinitis + atopic dermatitis were associated with a lower risk of psychiatric disorders, but all the other four groups, such as bronchial asthma alone, allergic rhinitis alone, bronchial asthma + allergic rhinitis, bronchial asthma + atopic dermatitis, and the combination of all these three allergic diseases, were associated with a higher risk of psychiatric disorders. CONCLUSION: Allergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan. |
format | Online Article Text |
id | pubmed-5928780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59287802018-05-08 Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study Tzeng, Nian-Sheng Chang, Hsin-An Chung, Chi-Hsiang Kao, Yu-Chen Chang, Chuan-Chia Yeh, Hui-Wen Chiang, Wei-Shan Chou, Yu-Ching Chang, Shan-Yueh Chien, Wu-Chien Front Psychiatry Psychiatry BACKGROUND/OBJECTIVE: Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan. METHODS: This cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000–2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray’s competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up. RESULTS: Of the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (p < 0.001). Fine and Gray’s competing risk model analysis revealed that the adjusted HR was 1.659 (95% CI = 1.602–1.717, p < 0.001). In this study, we found that the groups of atopic dermatitis alone and the allergic rhinitis + atopic dermatitis were associated with a lower risk of psychiatric disorders, but all the other four groups, such as bronchial asthma alone, allergic rhinitis alone, bronchial asthma + allergic rhinitis, bronchial asthma + atopic dermatitis, and the combination of all these three allergic diseases, were associated with a higher risk of psychiatric disorders. CONCLUSION: Allergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan. Frontiers Media S.A. 2018-04-24 /pmc/articles/PMC5928780/ /pubmed/29740354 http://dx.doi.org/10.3389/fpsyt.2018.00133 Text en Copyright © 2018 Tzeng, Chang, Chung, Kao, Chang, Yeh, Chiang, Chou, Chang and Chien. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Tzeng, Nian-Sheng Chang, Hsin-An Chung, Chi-Hsiang Kao, Yu-Chen Chang, Chuan-Chia Yeh, Hui-Wen Chiang, Wei-Shan Chou, Yu-Ching Chang, Shan-Yueh Chien, Wu-Chien Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title | Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title_full | Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title_fullStr | Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title_full_unstemmed | Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title_short | Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study |
title_sort | increased risk of psychiatric disorders in allergic diseases: a nationwide, population-based, cohort study |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928780/ https://www.ncbi.nlm.nih.gov/pubmed/29740354 http://dx.doi.org/10.3389/fpsyt.2018.00133 |
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