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Effect of Statins on Survival Following Stroke in Patients With Cancer
The objective of this study was to investigate the potential benefits of statin therapy initiation in acute stroke in patients with active cancer. This study was conducted in two parts. First, data from patients who are presented with stroke and active cancer were obtained from prospectively collect...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928845/ https://www.ncbi.nlm.nih.gov/pubmed/29740381 http://dx.doi.org/10.3389/fneur.2018.00205 |
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author | Kim, Ye Sel Park, Moo-Seok Lee, Jun-Hwa Chung, Jong-Won Lee, Mi Ji Kim, Chi Kyung Jung, Jin-Man Oh, Kyungmi Bang, Oh Young Kim, Geong-Moon Choi, Ji-Mi Lee, Juneyoung Chung, Chin Sang Lee, Kwang Ho Seo, Woo-Keun |
author_facet | Kim, Ye Sel Park, Moo-Seok Lee, Jun-Hwa Chung, Jong-Won Lee, Mi Ji Kim, Chi Kyung Jung, Jin-Man Oh, Kyungmi Bang, Oh Young Kim, Geong-Moon Choi, Ji-Mi Lee, Juneyoung Chung, Chin Sang Lee, Kwang Ho Seo, Woo-Keun |
author_sort | Kim, Ye Sel |
collection | PubMed |
description | The objective of this study was to investigate the potential benefits of statin therapy initiation in acute stroke in patients with active cancer. This study was conducted in two parts. First, data from patients who are presented with stroke and active cancer were obtained from prospectively collected multicenter hospital-based stroke registries. Patients were classified into statin user and non-user groups; the statin group was further divided into low-potency and high-potency statin subgroups. The primary outcome was time to mortality. Second, we obtained data from the Korean National Health Information Service-National Sample Cohort (NHIS-NSC) database for external validation and analyzed the effect of statins on mortality, taking compliance into consideration. For the stroke registry cohort, statin use was independently associated with reduced mortality in a multivariable model [hazard ratio (HR) = 0.675, 95% confidence interval (CI) = 0.457–0.996]. There was no interaction between statin use and cancer characteristics, vascular risk factors, or laboratory findings. A dose-dependent relationship between statin use and survival was also demonstrated. Analysis of the NHIS-NSC database found a similar association between statin therapy and reduced mortality (adjusted HR = 0.64, 95% CI = 0.45–0.90) and this effect persisted even after controlling for the adherence of statin use (HR = 0.60, 95% CI = 0.41–0.89). Statin therapy could be associated with reduced mortality in patients with acute stroke and active cancer. |
format | Online Article Text |
id | pubmed-5928845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59288452018-05-08 Effect of Statins on Survival Following Stroke in Patients With Cancer Kim, Ye Sel Park, Moo-Seok Lee, Jun-Hwa Chung, Jong-Won Lee, Mi Ji Kim, Chi Kyung Jung, Jin-Man Oh, Kyungmi Bang, Oh Young Kim, Geong-Moon Choi, Ji-Mi Lee, Juneyoung Chung, Chin Sang Lee, Kwang Ho Seo, Woo-Keun Front Neurol Neuroscience The objective of this study was to investigate the potential benefits of statin therapy initiation in acute stroke in patients with active cancer. This study was conducted in two parts. First, data from patients who are presented with stroke and active cancer were obtained from prospectively collected multicenter hospital-based stroke registries. Patients were classified into statin user and non-user groups; the statin group was further divided into low-potency and high-potency statin subgroups. The primary outcome was time to mortality. Second, we obtained data from the Korean National Health Information Service-National Sample Cohort (NHIS-NSC) database for external validation and analyzed the effect of statins on mortality, taking compliance into consideration. For the stroke registry cohort, statin use was independently associated with reduced mortality in a multivariable model [hazard ratio (HR) = 0.675, 95% confidence interval (CI) = 0.457–0.996]. There was no interaction between statin use and cancer characteristics, vascular risk factors, or laboratory findings. A dose-dependent relationship between statin use and survival was also demonstrated. Analysis of the NHIS-NSC database found a similar association between statin therapy and reduced mortality (adjusted HR = 0.64, 95% CI = 0.45–0.90) and this effect persisted even after controlling for the adherence of statin use (HR = 0.60, 95% CI = 0.41–0.89). Statin therapy could be associated with reduced mortality in patients with acute stroke and active cancer. Frontiers Media S.A. 2018-04-24 /pmc/articles/PMC5928845/ /pubmed/29740381 http://dx.doi.org/10.3389/fneur.2018.00205 Text en Copyright © 2018 Kim, Park, Lee, Chung, Lee, Kim, Jung, Oh, Bang, Kim, Choi, Lee, Chung, Lee and Seo. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kim, Ye Sel Park, Moo-Seok Lee, Jun-Hwa Chung, Jong-Won Lee, Mi Ji Kim, Chi Kyung Jung, Jin-Man Oh, Kyungmi Bang, Oh Young Kim, Geong-Moon Choi, Ji-Mi Lee, Juneyoung Chung, Chin Sang Lee, Kwang Ho Seo, Woo-Keun Effect of Statins on Survival Following Stroke in Patients With Cancer |
title | Effect of Statins on Survival Following Stroke in Patients With Cancer |
title_full | Effect of Statins on Survival Following Stroke in Patients With Cancer |
title_fullStr | Effect of Statins on Survival Following Stroke in Patients With Cancer |
title_full_unstemmed | Effect of Statins on Survival Following Stroke in Patients With Cancer |
title_short | Effect of Statins on Survival Following Stroke in Patients With Cancer |
title_sort | effect of statins on survival following stroke in patients with cancer |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928845/ https://www.ncbi.nlm.nih.gov/pubmed/29740381 http://dx.doi.org/10.3389/fneur.2018.00205 |
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