Amino Acid Uptake Measured by [(18)F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas

Rational: In a subset of cancers, arginine auxotrophy occurs due to the loss of expression of argininosuccinate synthetase 1 (ASS1). This loss of ASS1 expression makes cancers sensitive to arginine starvation that is induced by PEGylated arginine deiminase (ADI-PEG20). Although ADI-PEG20 treatment i...

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Detalles Bibliográficos
Autores principales: Prudner, Bethany Cheree, Sun, Fangdi, Kremer, Jeffrey Charles, Xu, Jinbin, Huang, Chaofeng, Sai, Kiran Kumar Solingapuram, Morgan, Zachary, Leeds, Hayden, McConathy, Jonathan, Van Tine, Brian Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928874/
https://www.ncbi.nlm.nih.gov/pubmed/29721066
http://dx.doi.org/10.7150/thno.22083

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