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Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway

Verteporfin, a FDA approved second-generation photosensitizer, has been demonstrated to have anticancer activity in various tumors, but not including papillary thyroid cancer (PTC). In current pre-clinical pilot study, we investigate the effect of verteporfin on proliferation, apoptosis, cell cycle...

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Autores principales: Liao, Tian, Wei, Wen-Jun, Wen, Duo, Hu, Jia-Qian, Wang, Yu, Ma, Ben, Cao, Yi-Min, Xiang, Jun, Guan, Qing, Chen, Jia-Ying, Sun, Guo-Hua, Zhu, Yong-Xue, Li, Duan-Shu, Ji, Qing-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929076/
https://www.ncbi.nlm.nih.gov/pubmed/29721041
http://dx.doi.org/10.7150/jca.21915
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author Liao, Tian
Wei, Wen-Jun
Wen, Duo
Hu, Jia-Qian
Wang, Yu
Ma, Ben
Cao, Yi-Min
Xiang, Jun
Guan, Qing
Chen, Jia-Ying
Sun, Guo-Hua
Zhu, Yong-Xue
Li, Duan-Shu
Ji, Qing-Hai
author_facet Liao, Tian
Wei, Wen-Jun
Wen, Duo
Hu, Jia-Qian
Wang, Yu
Ma, Ben
Cao, Yi-Min
Xiang, Jun
Guan, Qing
Chen, Jia-Ying
Sun, Guo-Hua
Zhu, Yong-Xue
Li, Duan-Shu
Ji, Qing-Hai
author_sort Liao, Tian
collection PubMed
description Verteporfin, a FDA approved second-generation photosensitizer, has been demonstrated to have anticancer activity in various tumors, but not including papillary thyroid cancer (PTC). In current pre-clinical pilot study, we investigate the effect of verteporfin on proliferation, apoptosis, cell cycle and tumor growth of PTC. Our results indicate verteporfin attenuates cell proliferation, arrests cell cycle in G2/S phase and induces apoptosis of PTC cells. Moreover, treatment of verteporfin dramatically suppresses tumor growth from PTC cells in xenograft mouse model. We further illustrate that exposure to MEK inhibitor U0126 inactivates phosphorylation of ERK1/2 and MEK in verteporfin-treated PTC cells. These data suggest verteporfin exhibits inhibitory effect on PTC cells proliferation and cell cycle partially via ERK1/2 signalling pathway, which strongly encourages the further application of verteporfin in the treatment against PTC.
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spelling pubmed-59290762018-05-02 Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway Liao, Tian Wei, Wen-Jun Wen, Duo Hu, Jia-Qian Wang, Yu Ma, Ben Cao, Yi-Min Xiang, Jun Guan, Qing Chen, Jia-Ying Sun, Guo-Hua Zhu, Yong-Xue Li, Duan-Shu Ji, Qing-Hai J Cancer Research Paper Verteporfin, a FDA approved second-generation photosensitizer, has been demonstrated to have anticancer activity in various tumors, but not including papillary thyroid cancer (PTC). In current pre-clinical pilot study, we investigate the effect of verteporfin on proliferation, apoptosis, cell cycle and tumor growth of PTC. Our results indicate verteporfin attenuates cell proliferation, arrests cell cycle in G2/S phase and induces apoptosis of PTC cells. Moreover, treatment of verteporfin dramatically suppresses tumor growth from PTC cells in xenograft mouse model. We further illustrate that exposure to MEK inhibitor U0126 inactivates phosphorylation of ERK1/2 and MEK in verteporfin-treated PTC cells. These data suggest verteporfin exhibits inhibitory effect on PTC cells proliferation and cell cycle partially via ERK1/2 signalling pathway, which strongly encourages the further application of verteporfin in the treatment against PTC. Ivyspring International Publisher 2018-03-29 /pmc/articles/PMC5929076/ /pubmed/29721041 http://dx.doi.org/10.7150/jca.21915 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liao, Tian
Wei, Wen-Jun
Wen, Duo
Hu, Jia-Qian
Wang, Yu
Ma, Ben
Cao, Yi-Min
Xiang, Jun
Guan, Qing
Chen, Jia-Ying
Sun, Guo-Hua
Zhu, Yong-Xue
Li, Duan-Shu
Ji, Qing-Hai
Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title_full Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title_fullStr Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title_full_unstemmed Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title_short Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
title_sort verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through erk1/2 signaling pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929076/
https://www.ncbi.nlm.nih.gov/pubmed/29721041
http://dx.doi.org/10.7150/jca.21915
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