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Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF

Breastfeeding is associated with a decreased risk of ovarian cancer. However, the mechanism underlying this apparent clinical benefit is unknown. Oxytocin (OXT), a hypothalamic nonapetide, plays a crucial role in many reproductive and behavioural functions. In recent year, OXT acts as a growth regul...

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Autores principales: Ji, Haoyi, Liu, Na, Yin, Yingchun, Wang, Xinmei, Chen, Xiaoyang, Li, Jing, Li, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929082/
https://www.ncbi.nlm.nih.gov/pubmed/29721047
http://dx.doi.org/10.7150/jca.23769
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author Ji, Haoyi
Liu, Na
Yin, Yingchun
Wang, Xinmei
Chen, Xiaoyang
Li, Jing
Li, Jingxin
author_facet Ji, Haoyi
Liu, Na
Yin, Yingchun
Wang, Xinmei
Chen, Xiaoyang
Li, Jing
Li, Jingxin
author_sort Ji, Haoyi
collection PubMed
description Breastfeeding is associated with a decreased risk of ovarian cancer. However, the mechanism underlying this apparent clinical benefit is unknown. Oxytocin (OXT), a hypothalamic nonapetide, plays a crucial role in many reproductive and behavioural functions. In recent year, OXT acts as a growth regulator in many kind of tumor tissues, through the activation of a specific G-coupled transmembrane receptor, the oxytocin receptor (OXTR). OXT has been proved to inhibit the proliferation, migration and invasion of ovarian cancer SKOV3 cells in vitro. But, the underlying mechanisms remain unknown. Here, we found OXT inhibited proliferation, and critically migration and invasion of human ovarian cancer cells SKOV3 and A2780. Strikingly, OXT inhibited ovarian cancer metastasis by repressing the expressions of MMP-2 and VEGF. Moreover, OXT inhibited vascular endothelial cell tube formation by reducing the VEGF production from ovarian cancer cells. Our findings may provide a possible explanation for breastfeeding-associated protective effects and suggest new therapeutic opportunities for ovarian cancer.
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spelling pubmed-59290822018-05-02 Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF Ji, Haoyi Liu, Na Yin, Yingchun Wang, Xinmei Chen, Xiaoyang Li, Jing Li, Jingxin J Cancer Research Paper Breastfeeding is associated with a decreased risk of ovarian cancer. However, the mechanism underlying this apparent clinical benefit is unknown. Oxytocin (OXT), a hypothalamic nonapetide, plays a crucial role in many reproductive and behavioural functions. In recent year, OXT acts as a growth regulator in many kind of tumor tissues, through the activation of a specific G-coupled transmembrane receptor, the oxytocin receptor (OXTR). OXT has been proved to inhibit the proliferation, migration and invasion of ovarian cancer SKOV3 cells in vitro. But, the underlying mechanisms remain unknown. Here, we found OXT inhibited proliferation, and critically migration and invasion of human ovarian cancer cells SKOV3 and A2780. Strikingly, OXT inhibited ovarian cancer metastasis by repressing the expressions of MMP-2 and VEGF. Moreover, OXT inhibited vascular endothelial cell tube formation by reducing the VEGF production from ovarian cancer cells. Our findings may provide a possible explanation for breastfeeding-associated protective effects and suggest new therapeutic opportunities for ovarian cancer. Ivyspring International Publisher 2018-04-06 /pmc/articles/PMC5929082/ /pubmed/29721047 http://dx.doi.org/10.7150/jca.23769 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Ji, Haoyi
Liu, Na
Yin, Yingchun
Wang, Xinmei
Chen, Xiaoyang
Li, Jing
Li, Jingxin
Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title_full Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title_fullStr Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title_full_unstemmed Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title_short Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
title_sort oxytocin inhibits ovarian cancer metastasis by repressing the expression of mmp-2 and vegf
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929082/
https://www.ncbi.nlm.nih.gov/pubmed/29721047
http://dx.doi.org/10.7150/jca.23769
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