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Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study
Background: When compared with patients harboring stage IIB and stage IIC disease, those with stage IIIA colorectal cancer have a better prognosis. We aimed to compare the cause-specific survival (CSS) of the patients with stage IIA rectal cancer with that of the patients with stage IIIA rectal canc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929092/ https://www.ncbi.nlm.nih.gov/pubmed/29721057 http://dx.doi.org/10.7150/jca.23311 |
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author | Mo, Shaobo Dai, Weixing Xiang, Wenqiang Huang, Ben Li, Yaqi Feng, Yang Li, Qingguo Cai, Guoxiang |
author_facet | Mo, Shaobo Dai, Weixing Xiang, Wenqiang Huang, Ben Li, Yaqi Feng, Yang Li, Qingguo Cai, Guoxiang |
author_sort | Mo, Shaobo |
collection | PubMed |
description | Background: When compared with patients harboring stage IIB and stage IIC disease, those with stage IIIA colorectal cancer have a better prognosis. We aimed to compare the cause-specific survival (CSS) of the patients with stage IIA rectal cancer with that of the patients with stage IIIA rectal cancer. Methods: Data analyzed about patients with stage IIA and stage IIIA rectal cancer was from the US Surveillance, Epidemiology, and End Results (SEER) database. We then validated the results using data derived from Fudan University Shanghai Cancer Center (FUSCC). Results: A total of 16,788 patients (13,551 staged IIA and 3,237 staged IIIA) were identified in SEER database. A multivariate analysis manifested that patients with stage IIIA disease were more likely to have a better CSS (HR 0.894, 95% CI 0.816-0.979, p=0.016) compared with patients with stage IIA rectal cancer. In the subgroup of patients whose number of lymph nodes harvested (LNH) <12, multivariate analysis signified that patients with stage IIIA disease were more prone to have favorable CSS (HR 0.805, 95% CI 0.719-0.901, p<0.001) compared with patients with stage IIA rectal cancer. In LNH≥12 subgroup, the Kaplan-Meier analysis revealed no significant difference between patients experiencing stage IIA and IIIA rectal cancer (p=0.618). Validation of data from FUSCC proved that patients with stage IIIA rectal cancer were more inclined to have better CSS (HR 0.407, 95% CI 0.187-0.885, p=0.019) in comparison to those with stage IIA rectal cancer. Specifically, in LNH<12 subgroup, the survival outcomes of stage IIIA patients were significantly better than that of the stage IIA patients (p=0.019), while there was no statistical significance between these two stages in the subgroup of patients with LNH≥12 (p=0.180). Conclusions: Patients with stage IIA rectal cancer have poorer CSS than patients with stage IIIA rectal cancer, particularly when inadequate lymph nodes are harvested. |
format | Online Article Text |
id | pubmed-5929092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-59290922018-05-02 Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study Mo, Shaobo Dai, Weixing Xiang, Wenqiang Huang, Ben Li, Yaqi Feng, Yang Li, Qingguo Cai, Guoxiang J Cancer Research Paper Background: When compared with patients harboring stage IIB and stage IIC disease, those with stage IIIA colorectal cancer have a better prognosis. We aimed to compare the cause-specific survival (CSS) of the patients with stage IIA rectal cancer with that of the patients with stage IIIA rectal cancer. Methods: Data analyzed about patients with stage IIA and stage IIIA rectal cancer was from the US Surveillance, Epidemiology, and End Results (SEER) database. We then validated the results using data derived from Fudan University Shanghai Cancer Center (FUSCC). Results: A total of 16,788 patients (13,551 staged IIA and 3,237 staged IIIA) were identified in SEER database. A multivariate analysis manifested that patients with stage IIIA disease were more likely to have a better CSS (HR 0.894, 95% CI 0.816-0.979, p=0.016) compared with patients with stage IIA rectal cancer. In the subgroup of patients whose number of lymph nodes harvested (LNH) <12, multivariate analysis signified that patients with stage IIIA disease were more prone to have favorable CSS (HR 0.805, 95% CI 0.719-0.901, p<0.001) compared with patients with stage IIA rectal cancer. In LNH≥12 subgroup, the Kaplan-Meier analysis revealed no significant difference between patients experiencing stage IIA and IIIA rectal cancer (p=0.618). Validation of data from FUSCC proved that patients with stage IIIA rectal cancer were more inclined to have better CSS (HR 0.407, 95% CI 0.187-0.885, p=0.019) in comparison to those with stage IIA rectal cancer. Specifically, in LNH<12 subgroup, the survival outcomes of stage IIIA patients were significantly better than that of the stage IIA patients (p=0.019), while there was no statistical significance between these two stages in the subgroup of patients with LNH≥12 (p=0.180). Conclusions: Patients with stage IIA rectal cancer have poorer CSS than patients with stage IIIA rectal cancer, particularly when inadequate lymph nodes are harvested. Ivyspring International Publisher 2018-04-06 /pmc/articles/PMC5929092/ /pubmed/29721057 http://dx.doi.org/10.7150/jca.23311 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Mo, Shaobo Dai, Weixing Xiang, Wenqiang Huang, Ben Li, Yaqi Feng, Yang Li, Qingguo Cai, Guoxiang Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title | Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title_full | Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title_fullStr | Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title_full_unstemmed | Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title_short | Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study |
title_sort | survival contradiction between stage iia and stage iiia rectal cancer: a retrospective study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929092/ https://www.ncbi.nlm.nih.gov/pubmed/29721057 http://dx.doi.org/10.7150/jca.23311 |
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