Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma

BACKGROUND: The Hedgehog (Hh) signaling pathway is active in esophageal adenocarcinoma (EAC). We used a patient-derived murine xenograft (PDX) model of EAC to evaluate tumour response to conventional treatment with radiation/chemoradiation with or without Hh inhibition. Our goal was to determine the...

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Detalles Bibliográficos
Autores principales: Teichman, Jennifer, Dodbiba, Lorin, Thai, Henry, Fleet, Andrew, Morey, Trevor, Liu, Lucy, McGregor, Madison, Cheng, Dangxiao, Chen, Zhuo, Darling, Gail, Brhane, Yonathan, Song, Yuyao, Espin-Garcia, Osvaldo, Xu, Wei, Girgis, Hala, Schwock, Joerg, MacKay, Helen, Bristow, Robert, Ailles, Laurie, Liu, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929523/
https://www.ncbi.nlm.nih.gov/pubmed/29715275
http://dx.doi.org/10.1371/journal.pone.0194809

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