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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

Pyrrole-imidazole (Py–Im) polyamides are synthetic non-genotoxic minor groove-binding small molecules. We hypothesized that Py–Im polyamides can modulate the cellular response to ionizing radiation. Pre-treatment of cells with a Py-Im polyamide prior to exposure to ionizing radiation resulted in a d...

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Detalles Bibliográficos
Autores principales:	Diaz-Perez, Silvia, Kane, Nathanael, Kurmis, Alexis A., Yang, Fei, Kummer, Nicolas T., Dervan, Peter B., Nickols, Nicholas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929528/ https://www.ncbi.nlm.nih.gov/pubmed/29715291 http://dx.doi.org/10.1371/journal.pone.0196803

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