Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments

T cells compete with malignant cells for limited nutrients within the solid tumor microenvironment. We found that effector memory CD4 T cells respond distinctly from other T cell subsets to limiting glucose and can maintain high levels of interferon-γ (IFN-γ) production in a nutrient-poor environmen...

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Detalles Bibliográficos
Autores principales: Ecker, Christopher, Guo, Lili, Voicu, Stefana, Gil-de-Gómez, Luis, Medvec, Andrew, Cortina, Luis, Pajda, Jackie, Andolina, Melanie, Torres-Castillo, Maria, Donato, Jennifer L., Mansour, Sarya, Zynda, Evan R., Lin, Pei-Yi, Varela-Rohena, Angel, Blair, Ian A., Riley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929999/
https://www.ncbi.nlm.nih.gov/pubmed/29669281
http://dx.doi.org/10.1016/j.celrep.2018.03.084

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