Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin

One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell‐free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false‐positive outcome for a normal, viable twin. We show that...

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Autores principales: Hochstenbach, Ron, Elferink, Martin G., van Zon, Patrick H. A., Lichtenbelt, Klaske D., van Harssel, Jeske, Schuring‐Blom, Heleen, Page‐Christiaens, Godelieve C.M.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930198/
https://www.ncbi.nlm.nih.gov/pubmed/29744057
http://dx.doi.org/10.1002/ccr3.1424
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author Hochstenbach, Ron
Elferink, Martin G.
van Zon, Patrick H. A.
Lichtenbelt, Klaske D.
van Harssel, Jeske
Schuring‐Blom, Heleen
Page‐Christiaens, Godelieve C.M.L.
author_facet Hochstenbach, Ron
Elferink, Martin G.
van Zon, Patrick H. A.
Lichtenbelt, Klaske D.
van Harssel, Jeske
Schuring‐Blom, Heleen
Page‐Christiaens, Godelieve C.M.L.
author_sort Hochstenbach, Ron
collection PubMed
description One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell‐free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false‐positive outcome for a normal, viable twin. We show that a vanishing trisomy‐14 twin contributes to cfDNA for more than 2 weeks after demise.
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spelling pubmed-59301982018-05-09 Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin Hochstenbach, Ron Elferink, Martin G. van Zon, Patrick H. A. Lichtenbelt, Klaske D. van Harssel, Jeske Schuring‐Blom, Heleen Page‐Christiaens, Godelieve C.M.L. Clin Case Rep Case Reports One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell‐free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false‐positive outcome for a normal, viable twin. We show that a vanishing trisomy‐14 twin contributes to cfDNA for more than 2 weeks after demise. John Wiley and Sons Inc. 2018-03-07 /pmc/articles/PMC5930198/ /pubmed/29744057 http://dx.doi.org/10.1002/ccr3.1424 Text en © 2018 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Hochstenbach, Ron
Elferink, Martin G.
van Zon, Patrick H. A.
Lichtenbelt, Klaske D.
van Harssel, Jeske
Schuring‐Blom, Heleen
Page‐Christiaens, Godelieve C.M.L.
Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title_full Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title_fullStr Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title_full_unstemmed Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title_short Discordant NIPT result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy‐14 cotwin
title_sort discordant nipt result in a viable trisomy‐21 pregnancy due to prolonged contribution to cfdna by a demised trisomy‐14 cotwin
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930198/
https://www.ncbi.nlm.nih.gov/pubmed/29744057
http://dx.doi.org/10.1002/ccr3.1424
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