Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants

PURPOSE: The clinical utility of screening unselected individuals for pathogenic BRCA1/2 variants has not been established. Data on cancer risk management behaviors and diagnoses of BRCA1/2-associated cancers can help inform assessments of clinical utility. METHODS: Whole-exome sequences of particip...

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Detalles Bibliográficos
Autores principales: Buchanan, Adam H, Manickam, Kandamurugu, Meyer, Michelle N, Wagner, Jennifer K, Hallquist, Miranda L G, Williams, Janet L, Rahm, Alanna Kulchak, Williams, Marc S, Chen, Zong-Ming E, Shah, Chaitali K, Garg, Tullika K, Lazzeri, Amanda L, Schwartz, Marci L B, Lindbuchler, D'Andra M, Fan, Audrey L, Leeming, Rosemary, Servano, Pedro O, Smith, Ashlee L, Vogel, Victor G, Abul-Husn, Noura S, Dewey, Frederick E, Lebo, Matthew S, Mason-Suares, Heather M, Ritchie, Marylyn D, Davis, F Daniel, Carey, David J, Feinberg, David T, Faucett, W Andrew, Ledbetter, David H, Murray, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930270/
https://www.ncbi.nlm.nih.gov/pubmed/29261187
http://dx.doi.org/10.1038/gim.2017.145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930270/
https://www.ncbi.nlm.nih.gov/pubmed/29261187
http://dx.doi.org/10.1038/gim.2017.145

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