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Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that is both ne...
Autores principales: | Athmer, Jeremiah, Fehr, Anthony R., Grunewald, Matthew E., Qu, Wen, Wheeler, D. Lori, Graepel, Kevin W., Channappanavar, Rudragouda, Sekine, Aimee, Aldabeeb, Dana Saud, Gale, Michael, Denison, Mark R., Perlman, Stanley |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930304/ https://www.ncbi.nlm.nih.gov/pubmed/29717007 http://dx.doi.org/10.1128/mBio.00272-18 |
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