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Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif
A dominant human gut microbe, the well studied symbiont Bacteroides thetaiotaomicron (Bt), is a glyco-specialist that harbors a large repertoire of genes devoted to carbohydrate processing. Despite strong similarities among them, many of the encoded enzymes have evolved distinct substrate specificit...
Autores principales: | Thompson, Andrew J., Spears, Richard J., Zhu, Yanping, Suits, Michael D. L., Williams, Spencer J., Gilbert, Harry J., Davies, Gideon J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930347/ https://www.ncbi.nlm.nih.gov/pubmed/29717710 http://dx.doi.org/10.1107/S2059798318002942 |
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