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HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer
Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer pati...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930459/ https://www.ncbi.nlm.nih.gov/pubmed/29725248 http://dx.doi.org/10.7150/ijms.23462 |
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author | Huang, Bi-Fei Tzeng, Huey-En Chen, Po-Chun Wang, Chao-Qun Su, Chen-Ming Wang, Yan Hu, Gui-Nv Zhao, Yong-Ming Wang, Qian Tang, Chih-Hsin |
author_facet | Huang, Bi-Fei Tzeng, Huey-En Chen, Po-Chun Wang, Chao-Qun Su, Chen-Ming Wang, Yan Hu, Gui-Nv Zhao, Yong-Ming Wang, Qian Tang, Chih-Hsin |
author_sort | Huang, Bi-Fei |
collection | PubMed |
description | Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 4 SNPs of the HMGB1 gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls. Patients with one G allele in the rs1360485 or rs2249825 domains are likely to progress to T2 tumor and lymph node metastasis. In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors. Furthermore, having one C allele in the rs1412125 domain increased the risk of pathologic grade 3 disease in HER2-enriched and TNBC tumors. Our results indicate that genetic variations in the HMGB1 gene may serve as an important predictor of breast cancer progression and metastasis. |
format | Online Article Text |
id | pubmed-5930459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-59304592018-05-03 HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer Huang, Bi-Fei Tzeng, Huey-En Chen, Po-Chun Wang, Chao-Qun Su, Chen-Ming Wang, Yan Hu, Gui-Nv Zhao, Yong-Ming Wang, Qian Tang, Chih-Hsin Int J Med Sci Research Paper Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 4 SNPs of the HMGB1 gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls. Patients with one G allele in the rs1360485 or rs2249825 domains are likely to progress to T2 tumor and lymph node metastasis. In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors. Furthermore, having one C allele in the rs1412125 domain increased the risk of pathologic grade 3 disease in HER2-enriched and TNBC tumors. Our results indicate that genetic variations in the HMGB1 gene may serve as an important predictor of breast cancer progression and metastasis. Ivyspring International Publisher 2018-03-12 /pmc/articles/PMC5930459/ /pubmed/29725248 http://dx.doi.org/10.7150/ijms.23462 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Huang, Bi-Fei Tzeng, Huey-En Chen, Po-Chun Wang, Chao-Qun Su, Chen-Ming Wang, Yan Hu, Gui-Nv Zhao, Yong-Ming Wang, Qian Tang, Chih-Hsin HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title | HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title_full | HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title_fullStr | HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title_full_unstemmed | HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title_short | HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
title_sort | hmgb1 genetic polymorphisms are biomarkers for the development and progression of breast cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930459/ https://www.ncbi.nlm.nih.gov/pubmed/29725248 http://dx.doi.org/10.7150/ijms.23462 |
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