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Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell l...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930473/ https://www.ncbi.nlm.nih.gov/pubmed/29725262 http://dx.doi.org/10.7150/ijbs.23542 |
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author | Wang, Fengjiao Liu, Wei Ning, Jinfeng Wang, Junfeng Lang, Yaoguo Jin, Xiangyuan Zhu, Kaibin Wang, Xiuyun Li, Xiaoguang Yang, Fan Ma, Jianqun Xu, Shidong |
author_facet | Wang, Fengjiao Liu, Wei Ning, Jinfeng Wang, Junfeng Lang, Yaoguo Jin, Xiangyuan Zhu, Kaibin Wang, Xiuyun Li, Xiaoguang Yang, Fan Ma, Jianqun Xu, Shidong |
author_sort | Wang, Fengjiao |
collection | PubMed |
description | Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC. |
format | Online Article Text |
id | pubmed-5930473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-59304732018-05-03 Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis Wang, Fengjiao Liu, Wei Ning, Jinfeng Wang, Junfeng Lang, Yaoguo Jin, Xiangyuan Zhu, Kaibin Wang, Xiuyun Li, Xiaoguang Yang, Fan Ma, Jianqun Xu, Shidong Int J Biol Sci Research Paper Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC. Ivyspring International Publisher 2018-03-10 /pmc/articles/PMC5930473/ /pubmed/29725262 http://dx.doi.org/10.7150/ijbs.23542 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Wang, Fengjiao Liu, Wei Ning, Jinfeng Wang, Junfeng Lang, Yaoguo Jin, Xiangyuan Zhu, Kaibin Wang, Xiuyun Li, Xiaoguang Yang, Fan Ma, Jianqun Xu, Shidong Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title | Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title_full | Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title_fullStr | Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title_full_unstemmed | Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title_short | Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis |
title_sort | simvastatin suppresses proliferation and migration in non-small cell lung cancer via pyroptosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930473/ https://www.ncbi.nlm.nih.gov/pubmed/29725262 http://dx.doi.org/10.7150/ijbs.23542 |
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