Cargando…

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell l...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Fengjiao, Liu, Wei, Ning, Jinfeng, Wang, Junfeng, Lang, Yaoguo, Jin, Xiangyuan, Zhu, Kaibin, Wang, Xiuyun, Li, Xiaoguang, Yang, Fan, Ma, Jianqun, Xu, Shidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930473/
https://www.ncbi.nlm.nih.gov/pubmed/29725262
http://dx.doi.org/10.7150/ijbs.23542
_version_ 1783319501565067264
author Wang, Fengjiao
Liu, Wei
Ning, Jinfeng
Wang, Junfeng
Lang, Yaoguo
Jin, Xiangyuan
Zhu, Kaibin
Wang, Xiuyun
Li, Xiaoguang
Yang, Fan
Ma, Jianqun
Xu, Shidong
author_facet Wang, Fengjiao
Liu, Wei
Ning, Jinfeng
Wang, Junfeng
Lang, Yaoguo
Jin, Xiangyuan
Zhu, Kaibin
Wang, Xiuyun
Li, Xiaoguang
Yang, Fan
Ma, Jianqun
Xu, Shidong
author_sort Wang, Fengjiao
collection PubMed
description Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC.
format Online
Article
Text
id pubmed-5930473
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-59304732018-05-03 Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis Wang, Fengjiao Liu, Wei Ning, Jinfeng Wang, Junfeng Lang, Yaoguo Jin, Xiangyuan Zhu, Kaibin Wang, Xiuyun Li, Xiaoguang Yang, Fan Ma, Jianqun Xu, Shidong Int J Biol Sci Research Paper Pyroptosis is a form of caspase-1-dependent programmed cell death with anti-tumor properties, but the underlying molecular mechanisms are not fully understood. The results of our study showed that the antihyperlipidemic drug simvastatin induced pyroptosis in non-small cell lung cancer (NSCLC) cell lines and a xenograft mouse model. Inhibition of pyroptosis attenuated the effects of simvastatin on tumor cell viability and migration. These data suggest that simvastatin may induce pyroptosis, thereby potentially serving as a novel therapeutic agent for NSCLC. Ivyspring International Publisher 2018-03-10 /pmc/articles/PMC5930473/ /pubmed/29725262 http://dx.doi.org/10.7150/ijbs.23542 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Fengjiao
Liu, Wei
Ning, Jinfeng
Wang, Junfeng
Lang, Yaoguo
Jin, Xiangyuan
Zhu, Kaibin
Wang, Xiuyun
Li, Xiaoguang
Yang, Fan
Ma, Jianqun
Xu, Shidong
Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title_full Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title_fullStr Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title_full_unstemmed Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title_short Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis
title_sort simvastatin suppresses proliferation and migration in non-small cell lung cancer via pyroptosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930473/
https://www.ncbi.nlm.nih.gov/pubmed/29725262
http://dx.doi.org/10.7150/ijbs.23542
work_keys_str_mv AT wangfengjiao simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT liuwei simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT ningjinfeng simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT wangjunfeng simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT langyaoguo simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT jinxiangyuan simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT zhukaibin simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT wangxiuyun simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT lixiaoguang simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT yangfan simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT majianqun simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis
AT xushidong simvastatinsuppressesproliferationandmigrationinnonsmallcelllungcancerviapyroptosis