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Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock

Systemic mastocytosis is a rare disease due to abnormal proliferation of mast cells (MCs). A case of indolent systemic mastocytosis is presented here. After anesthetic induction for elective thyroid swelling with propofol and atracurium followed by endotracheal intubation, a 57-year-old female patie...

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Autores principales: Chatterjee, Manidipam, Sengupta, Saikat, Chakravarty, Chandrashish, Ramasubban, Suresh, Bhartia, Shilpa, Khan, Sujoy, Agarwal, Vikash Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930539/
https://www.ncbi.nlm.nih.gov/pubmed/29743774
http://dx.doi.org/10.4103/ijccm.IJCCM_497_17
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author Chatterjee, Manidipam
Sengupta, Saikat
Chakravarty, Chandrashish
Ramasubban, Suresh
Bhartia, Shilpa
Khan, Sujoy
Agarwal, Vikash Kumar
author_facet Chatterjee, Manidipam
Sengupta, Saikat
Chakravarty, Chandrashish
Ramasubban, Suresh
Bhartia, Shilpa
Khan, Sujoy
Agarwal, Vikash Kumar
author_sort Chatterjee, Manidipam
collection PubMed
description Systemic mastocytosis is a rare disease due to abnormal proliferation of mast cells (MCs). A case of indolent systemic mastocytosis is presented here. After anesthetic induction for elective thyroid swelling with propofol and atracurium followed by endotracheal intubation, a 57-year-old female patient developed acute hypotension, sinus tachycardia, red rashes, increased airway pressure along with difficult ventilation, and desaturation. She developed multiorgan failure subsequently. MC tryptase level was persistently high. Bone marrow study revealed mastocytosis. She required antihistaminic, steroid, and organ support. With treatment, organ functions recovered gradually. Atracurium precipitated anaphylactic shock causing severe morbidity in this patient.
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spelling pubmed-59305392018-05-09 Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock Chatterjee, Manidipam Sengupta, Saikat Chakravarty, Chandrashish Ramasubban, Suresh Bhartia, Shilpa Khan, Sujoy Agarwal, Vikash Kumar Indian J Crit Care Med Case Report Systemic mastocytosis is a rare disease due to abnormal proliferation of mast cells (MCs). A case of indolent systemic mastocytosis is presented here. After anesthetic induction for elective thyroid swelling with propofol and atracurium followed by endotracheal intubation, a 57-year-old female patient developed acute hypotension, sinus tachycardia, red rashes, increased airway pressure along with difficult ventilation, and desaturation. She developed multiorgan failure subsequently. MC tryptase level was persistently high. Bone marrow study revealed mastocytosis. She required antihistaminic, steroid, and organ support. With treatment, organ functions recovered gradually. Atracurium precipitated anaphylactic shock causing severe morbidity in this patient. Medknow Publications & Media Pvt Ltd 2018-04 /pmc/articles/PMC5930539/ /pubmed/29743774 http://dx.doi.org/10.4103/ijccm.IJCCM_497_17 Text en Copyright: © 2018 Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Chatterjee, Manidipam
Sengupta, Saikat
Chakravarty, Chandrashish
Ramasubban, Suresh
Bhartia, Shilpa
Khan, Sujoy
Agarwal, Vikash Kumar
Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title_full Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title_fullStr Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title_full_unstemmed Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title_short Indolent Systemic Mastocytosis Manifesting as Protracted Anaphylactic Shock
title_sort indolent systemic mastocytosis manifesting as protracted anaphylactic shock
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930539/
https://www.ncbi.nlm.nih.gov/pubmed/29743774
http://dx.doi.org/10.4103/ijccm.IJCCM_497_17
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