Best PEEP trials are dependent on tidal volume

ABSTRACT: Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other v...

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Detalles Bibliográficos
Autores principales: McKown, Andrew C., Semler, Matthew W., Rice, Todd W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930668/
https://www.ncbi.nlm.nih.gov/pubmed/29720277
http://dx.doi.org/10.1186/s13054-018-2047-4
Descripción
Sumario:ABSTRACT: Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02871102. Registered on 12 August 2016.

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