Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

BACKGROUND: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized that exosome-bound T-DM1 may contribute to the activity of T-DM1. METHODS: Exoso...

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Detalles Bibliográficos
Autores principales: Barok, Mark, Puhka, Maija, Vereb, Gyorgy, Szollosi, Janos, Isola, Jorma, Joensuu, Heikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930687/
https://www.ncbi.nlm.nih.gov/pubmed/29720111
http://dx.doi.org/10.1186/s12885-018-4418-2

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