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A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

BACKGROUND: Gastric cancer is the leading cause of cancer related death worldwide. Radiation alone or combined with chemotherapy plays important role in locally advanced and metastatic gastric adenocarcinoma. MDM2–p53 interaction and downstream signaling affect cellular response to DNA damage which...

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Detalles Bibliográficos
Autores principales:	Yi, Hanjie, Yan, Xianglei, Luo, Qiuyun, Yuan, Luping, Li, Baoxia, Pan, Wentao, Zhang, Lin, Chen, Haibo, Wang, Jing, Zhang, Yubin, Zhai, Yifan, Qiu, Miao-Zhen, Yang, Da-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930807/ https://www.ncbi.nlm.nih.gov/pubmed/29716622 http://dx.doi.org/10.1186/s13046-018-0765-8

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