Cargando…

α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction

α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role of α6-containing integrins (α6β1 and α6β4) in the regulation of stem cell properties, lineag...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Zijing, Qu, Jing, He, Li, Peng, Hong, Chen, Ping, Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930856/
https://www.ncbi.nlm.nih.gov/pubmed/29720266
http://dx.doi.org/10.1186/s13287-018-0868-3
_version_ 1783319553948778496
author Zhou, Zijing
Qu, Jing
He, Li
Peng, Hong
Chen, Ping
Zhou, Yong
author_facet Zhou, Zijing
Qu, Jing
He, Li
Peng, Hong
Chen, Ping
Zhou, Yong
author_sort Zhou, Zijing
collection PubMed
description α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role of α6-containing integrins (α6β1 and α6β4) in the regulation of stem cell properties, lineage-specific differentiation, and niche interaction. α6-Integrin subunit can be alternatively spliced at the post-transcriptional level, giving rise to divergent isoforms which differ in the cytoplasmic and/or extracellular domains. The cytoplasmic domain of integrins is an important functional part of integrin-mediated signals. Structural changes in the cytoplasmic domain of α6 provide an efficient means for the regulation of stem cell responses to biochemical stimuli and/or biophysical cues in the stem cell niche, thus impacting stem cell fate determination. In this review, we summarize the current knowledge on the structural variants of the α6-integrin subunit and spatiotemporal expression of α6 cytoplasmic variants in embryonic and adult stem/progenitor cells. We highlight the roles of α6 cytoplasmic variants in stem cell fate decision and niche interaction, and discuss the potential mechanisms involved. Understanding of the distinct functions of α6 splicing variants in stem cell biology may inform the rational design of novel stem cell-based therapies for a range of human diseases.
format Online
Article
Text
id pubmed-5930856
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-59308562018-05-09 α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction Zhou, Zijing Qu, Jing He, Li Peng, Hong Chen, Ping Zhou, Yong Stem Cell Res Ther Review α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role of α6-containing integrins (α6β1 and α6β4) in the regulation of stem cell properties, lineage-specific differentiation, and niche interaction. α6-Integrin subunit can be alternatively spliced at the post-transcriptional level, giving rise to divergent isoforms which differ in the cytoplasmic and/or extracellular domains. The cytoplasmic domain of integrins is an important functional part of integrin-mediated signals. Structural changes in the cytoplasmic domain of α6 provide an efficient means for the regulation of stem cell responses to biochemical stimuli and/or biophysical cues in the stem cell niche, thus impacting stem cell fate determination. In this review, we summarize the current knowledge on the structural variants of the α6-integrin subunit and spatiotemporal expression of α6 cytoplasmic variants in embryonic and adult stem/progenitor cells. We highlight the roles of α6 cytoplasmic variants in stem cell fate decision and niche interaction, and discuss the potential mechanisms involved. Understanding of the distinct functions of α6 splicing variants in stem cell biology may inform the rational design of novel stem cell-based therapies for a range of human diseases. BioMed Central 2018-05-02 /pmc/articles/PMC5930856/ /pubmed/29720266 http://dx.doi.org/10.1186/s13287-018-0868-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhou, Zijing
Qu, Jing
He, Li
Peng, Hong
Chen, Ping
Zhou, Yong
α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title_full α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title_fullStr α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title_full_unstemmed α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title_short α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
title_sort α6-integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930856/
https://www.ncbi.nlm.nih.gov/pubmed/29720266
http://dx.doi.org/10.1186/s13287-018-0868-3
work_keys_str_mv AT zhouzijing a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction
AT qujing a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction
AT heli a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction
AT penghong a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction
AT chenping a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction
AT zhouyong a6integrinalternativesplicingdistinctcytoplasmicvariantsinstemcellfatespecificationandnicheinteraction