The case for not masking away repetitive DNA

In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results. This Commentary is a plea from one member of the Mobile...

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Detalles Bibliográficos
Autor principal: Slotkin, R. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930866/
https://www.ncbi.nlm.nih.gov/pubmed/29743957
http://dx.doi.org/10.1186/s13100-018-0120-9
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author Slotkin, R. Keith
author_facet Slotkin, R. Keith
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description In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results. This Commentary is a plea from one member of the Mobile DNA community to all gene-centric researchers: please do not ignore the repetitive fraction of the genome. Please stop narrowing your findings by only analyzing a minority of the genome, and instead broaden your analyses to include the rich biology of repetitive and mobile DNA. In this article, I present four arguments supporting a case for retaining repetitive DNA in your genome-wide analysis.
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spelling pubmed-59308662018-05-09 The case for not masking away repetitive DNA Slotkin, R. Keith Mob DNA Commentary In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results. This Commentary is a plea from one member of the Mobile DNA community to all gene-centric researchers: please do not ignore the repetitive fraction of the genome. Please stop narrowing your findings by only analyzing a minority of the genome, and instead broaden your analyses to include the rich biology of repetitive and mobile DNA. In this article, I present four arguments supporting a case for retaining repetitive DNA in your genome-wide analysis. BioMed Central 2018-05-01 /pmc/articles/PMC5930866/ /pubmed/29743957 http://dx.doi.org/10.1186/s13100-018-0120-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Slotkin, R. Keith
The case for not masking away repetitive DNA
title The case for not masking away repetitive DNA
title_full The case for not masking away repetitive DNA
title_fullStr The case for not masking away repetitive DNA
title_full_unstemmed The case for not masking away repetitive DNA
title_short The case for not masking away repetitive DNA
title_sort case for not masking away repetitive dna
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930866/
https://www.ncbi.nlm.nih.gov/pubmed/29743957
http://dx.doi.org/10.1186/s13100-018-0120-9
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