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Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian C...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931085/ https://www.ncbi.nlm.nih.gov/pubmed/29555990 http://dx.doi.org/10.1038/s41416-018-0011-3 |
| _version_ | 1783319591015940096 |
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| author | Dixon-Suen, Suzanne C. Nagle, Christina M. Thrift, Aaron P. Pharoah, Paul D. P. Ewing, Ailith Pearce, Celeste Leigh Zheng, Wei Chenevix-Trench, Georgia Fasching, Peter A. Beckmann, Matthias W. Lambrechts, Diether Vergote, Ignace Lambrechts, Sandrina Van Nieuwenhuysen, Els Rossing, Mary Anne Doherty, Jennifer A. Wicklund, Kristine G. Chang-Claude, Jenny Jung, Audrey Y. Moysich, Kirsten B. Odunsi, Kunle Goodman, Marc T. Wilkens, Lynne R. Thompson, Pamela J. Shvetsov, Yurii B. Dörk, Thilo Park-Simon, Tjoung-Won Hillemanns, Peter Bogdanova, Natalia Butzow, Ralf Nevanlinna, Heli Pelttari, Liisa M. Leminen, Arto Modugno, Francesmary Ness, Roberta B. Edwards, Robert P. Kelley, Joseph L. Heitz, Florian du Bois, Andreas Harter, Philipp Schwaab, Ira Karlan, Beth Y. Lester, Jenny Orsulic, Sandra Rimel, Bobbie J. Kjær, Susanne K. Høgdall, Estrid Jensen, Allan Goode, Ellen L. Fridley, Brooke L. Cunningham, Julie M. Winham, Stacey J. Giles, Graham G. Bruinsma, Fiona Milne, Roger L. Southey, Melissa C. Hildebrandt, Michelle A. T. Wu, Xifeng Lu, Karen H. Liang, Dong Levine, Douglas A. Bisogna, Maria Schildkraut, Joellen M. Berchuck, Andrew Cramer, Daniel W. Terry, Kathryn L. Bandera, Elisa V. Olson, Sara H. Salvesen, Helga B. Thomsen, Liv Cecilie Vestrheim Kopperud, Reidun K. Bjorge, Line Kiemeney, Lambertus A. Massuger, Leon F. A. G. Pejovic, Tanja Bruegl, Amanda Cook, Linda S. Le, Nhu D. Swenerton, Kenneth D. Brooks-Wilson, Angela Kelemen, Linda E. Lubiński, Jan Huzarski, Tomasz Gronwald, Jacek Menkiszak, Janusz Wentzensen, Nicolas Brinton, Louise Yang, Hannah Lissowska, Jolanta Høgdall, Claus K. Lundvall, Lene Song, Honglin Tyrer, Jonathan P. Campbell, Ian Eccles, Diana Paul, James Glasspool, Rosalind Siddiqui, Nadeem Whittemore, Alice S. Sieh, Weiva McGuire, Valerie Rothstein, Joseph H. Narod, Steven A. Phelan, Catherine Risch, Harvey A. McLaughlin, John R. Anton-Culver, Hoda Ziogas, Argyrios Menon, Usha Gayther, Simon A. Ramus, Susan J. Gentry-Maharaj, Aleksandra Wu, Anna H. Pike, Malcolm C. Tseng, Chiu-Chen Kupryjanczyk, Jolanta Dansonka-Mieszkowska, Agnieszka Budzilowska, Agnieszka Rzepecka, Iwona K. Webb, Penelope M. |
| author_facet | Dixon-Suen, Suzanne C. Nagle, Christina M. Thrift, Aaron P. Pharoah, Paul D. P. Ewing, Ailith Pearce, Celeste Leigh Zheng, Wei Chenevix-Trench, Georgia Fasching, Peter A. Beckmann, Matthias W. Lambrechts, Diether Vergote, Ignace Lambrechts, Sandrina Van Nieuwenhuysen, Els Rossing, Mary Anne Doherty, Jennifer A. Wicklund, Kristine G. Chang-Claude, Jenny Jung, Audrey Y. Moysich, Kirsten B. Odunsi, Kunle Goodman, Marc T. Wilkens, Lynne R. Thompson, Pamela J. Shvetsov, Yurii B. Dörk, Thilo Park-Simon, Tjoung-Won Hillemanns, Peter Bogdanova, Natalia Butzow, Ralf Nevanlinna, Heli Pelttari, Liisa M. Leminen, Arto Modugno, Francesmary Ness, Roberta B. Edwards, Robert P. Kelley, Joseph L. Heitz, Florian du Bois, Andreas Harter, Philipp Schwaab, Ira Karlan, Beth Y. Lester, Jenny Orsulic, Sandra Rimel, Bobbie J. Kjær, Susanne K. Høgdall, Estrid Jensen, Allan Goode, Ellen L. Fridley, Brooke L. Cunningham, Julie M. Winham, Stacey J. Giles, Graham G. Bruinsma, Fiona Milne, Roger L. Southey, Melissa C. Hildebrandt, Michelle A. T. Wu, Xifeng Lu, Karen H. Liang, Dong Levine, Douglas A. Bisogna, Maria Schildkraut, Joellen M. Berchuck, Andrew Cramer, Daniel W. Terry, Kathryn L. Bandera, Elisa V. Olson, Sara H. Salvesen, Helga B. Thomsen, Liv Cecilie Vestrheim Kopperud, Reidun K. Bjorge, Line Kiemeney, Lambertus A. Massuger, Leon F. A. G. Pejovic, Tanja Bruegl, Amanda Cook, Linda S. Le, Nhu D. Swenerton, Kenneth D. Brooks-Wilson, Angela Kelemen, Linda E. Lubiński, Jan Huzarski, Tomasz Gronwald, Jacek Menkiszak, Janusz Wentzensen, Nicolas Brinton, Louise Yang, Hannah Lissowska, Jolanta Høgdall, Claus K. Lundvall, Lene Song, Honglin Tyrer, Jonathan P. Campbell, Ian Eccles, Diana Paul, James Glasspool, Rosalind Siddiqui, Nadeem Whittemore, Alice S. Sieh, Weiva McGuire, Valerie Rothstein, Joseph H. Narod, Steven A. Phelan, Catherine Risch, Harvey A. McLaughlin, John R. Anton-Culver, Hoda Ziogas, Argyrios Menon, Usha Gayther, Simon A. Ramus, Susan J. Gentry-Maharaj, Aleksandra Wu, Anna H. Pike, Malcolm C. Tseng, Chiu-Chen Kupryjanczyk, Jolanta Dansonka-Mieszkowska, Agnieszka Budzilowska, Agnieszka Rzepecka, Iwona K. Webb, Penelope M. |
| author_sort | Dixon-Suen, Suzanne C. |
| collection | PubMed |
| description | BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01–1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01–1.11) and borderline (pOR = 1.15; 95% CI: 1.02–1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis. |
| format | Online Article Text |
| id | pubmed-5931085 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59310852019-04-15 Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study Dixon-Suen, Suzanne C. Nagle, Christina M. Thrift, Aaron P. Pharoah, Paul D. P. Ewing, Ailith Pearce, Celeste Leigh Zheng, Wei Chenevix-Trench, Georgia Fasching, Peter A. Beckmann, Matthias W. Lambrechts, Diether Vergote, Ignace Lambrechts, Sandrina Van Nieuwenhuysen, Els Rossing, Mary Anne Doherty, Jennifer A. Wicklund, Kristine G. Chang-Claude, Jenny Jung, Audrey Y. Moysich, Kirsten B. Odunsi, Kunle Goodman, Marc T. Wilkens, Lynne R. Thompson, Pamela J. Shvetsov, Yurii B. Dörk, Thilo Park-Simon, Tjoung-Won Hillemanns, Peter Bogdanova, Natalia Butzow, Ralf Nevanlinna, Heli Pelttari, Liisa M. Leminen, Arto Modugno, Francesmary Ness, Roberta B. Edwards, Robert P. Kelley, Joseph L. Heitz, Florian du Bois, Andreas Harter, Philipp Schwaab, Ira Karlan, Beth Y. Lester, Jenny Orsulic, Sandra Rimel, Bobbie J. Kjær, Susanne K. Høgdall, Estrid Jensen, Allan Goode, Ellen L. Fridley, Brooke L. Cunningham, Julie M. Winham, Stacey J. Giles, Graham G. Bruinsma, Fiona Milne, Roger L. Southey, Melissa C. Hildebrandt, Michelle A. T. Wu, Xifeng Lu, Karen H. Liang, Dong Levine, Douglas A. Bisogna, Maria Schildkraut, Joellen M. Berchuck, Andrew Cramer, Daniel W. Terry, Kathryn L. Bandera, Elisa V. Olson, Sara H. Salvesen, Helga B. Thomsen, Liv Cecilie Vestrheim Kopperud, Reidun K. Bjorge, Line Kiemeney, Lambertus A. Massuger, Leon F. A. G. Pejovic, Tanja Bruegl, Amanda Cook, Linda S. Le, Nhu D. Swenerton, Kenneth D. Brooks-Wilson, Angela Kelemen, Linda E. Lubiński, Jan Huzarski, Tomasz Gronwald, Jacek Menkiszak, Janusz Wentzensen, Nicolas Brinton, Louise Yang, Hannah Lissowska, Jolanta Høgdall, Claus K. Lundvall, Lene Song, Honglin Tyrer, Jonathan P. Campbell, Ian Eccles, Diana Paul, James Glasspool, Rosalind Siddiqui, Nadeem Whittemore, Alice S. Sieh, Weiva McGuire, Valerie Rothstein, Joseph H. Narod, Steven A. Phelan, Catherine Risch, Harvey A. McLaughlin, John R. Anton-Culver, Hoda Ziogas, Argyrios Menon, Usha Gayther, Simon A. Ramus, Susan J. Gentry-Maharaj, Aleksandra Wu, Anna H. Pike, Malcolm C. Tseng, Chiu-Chen Kupryjanczyk, Jolanta Dansonka-Mieszkowska, Agnieszka Budzilowska, Agnieszka Rzepecka, Iwona K. Webb, Penelope M. Br J Cancer Article BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01–1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01–1.11) and borderline (pOR = 1.15; 95% CI: 1.02–1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis. Nature Publishing Group UK 2018-03-20 2018-04-17 /pmc/articles/PMC5931085/ /pubmed/29555990 http://dx.doi.org/10.1038/s41416-018-0011-3 Text en © Cancer Research UK 2018 https://creativecommons.org/licenses/by/4.0/Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International licence (CC BY 4.0). |
| spellingShingle | Article Dixon-Suen, Suzanne C. Nagle, Christina M. Thrift, Aaron P. Pharoah, Paul D. P. Ewing, Ailith Pearce, Celeste Leigh Zheng, Wei Chenevix-Trench, Georgia Fasching, Peter A. Beckmann, Matthias W. Lambrechts, Diether Vergote, Ignace Lambrechts, Sandrina Van Nieuwenhuysen, Els Rossing, Mary Anne Doherty, Jennifer A. Wicklund, Kristine G. Chang-Claude, Jenny Jung, Audrey Y. Moysich, Kirsten B. Odunsi, Kunle Goodman, Marc T. Wilkens, Lynne R. Thompson, Pamela J. Shvetsov, Yurii B. Dörk, Thilo Park-Simon, Tjoung-Won Hillemanns, Peter Bogdanova, Natalia Butzow, Ralf Nevanlinna, Heli Pelttari, Liisa M. Leminen, Arto Modugno, Francesmary Ness, Roberta B. Edwards, Robert P. Kelley, Joseph L. Heitz, Florian du Bois, Andreas Harter, Philipp Schwaab, Ira Karlan, Beth Y. Lester, Jenny Orsulic, Sandra Rimel, Bobbie J. Kjær, Susanne K. Høgdall, Estrid Jensen, Allan Goode, Ellen L. Fridley, Brooke L. Cunningham, Julie M. Winham, Stacey J. Giles, Graham G. Bruinsma, Fiona Milne, Roger L. Southey, Melissa C. Hildebrandt, Michelle A. T. Wu, Xifeng Lu, Karen H. Liang, Dong Levine, Douglas A. Bisogna, Maria Schildkraut, Joellen M. Berchuck, Andrew Cramer, Daniel W. Terry, Kathryn L. Bandera, Elisa V. Olson, Sara H. Salvesen, Helga B. Thomsen, Liv Cecilie Vestrheim Kopperud, Reidun K. Bjorge, Line Kiemeney, Lambertus A. Massuger, Leon F. A. G. Pejovic, Tanja Bruegl, Amanda Cook, Linda S. Le, Nhu D. Swenerton, Kenneth D. Brooks-Wilson, Angela Kelemen, Linda E. Lubiński, Jan Huzarski, Tomasz Gronwald, Jacek Menkiszak, Janusz Wentzensen, Nicolas Brinton, Louise Yang, Hannah Lissowska, Jolanta Høgdall, Claus K. Lundvall, Lene Song, Honglin Tyrer, Jonathan P. Campbell, Ian Eccles, Diana Paul, James Glasspool, Rosalind Siddiqui, Nadeem Whittemore, Alice S. Sieh, Weiva McGuire, Valerie Rothstein, Joseph H. Narod, Steven A. Phelan, Catherine Risch, Harvey A. McLaughlin, John R. Anton-Culver, Hoda Ziogas, Argyrios Menon, Usha Gayther, Simon A. Ramus, Susan J. Gentry-Maharaj, Aleksandra Wu, Anna H. Pike, Malcolm C. Tseng, Chiu-Chen Kupryjanczyk, Jolanta Dansonka-Mieszkowska, Agnieszka Budzilowska, Agnieszka Rzepecka, Iwona K. Webb, Penelope M. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title | Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title_full | Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title_fullStr | Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title_full_unstemmed | Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title_short | Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study |
| title_sort | adult height is associated with increased risk of ovarian cancer: a mendelian randomisation study |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931085/ https://www.ncbi.nlm.nih.gov/pubmed/29555990 http://dx.doi.org/10.1038/s41416-018-0011-3 |
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