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Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression

BACKGROUND: Zinc-finger protein 384 (ZNF384) fusions are an emerging subtype of precursor B-cell acute lymphoblastic leukaemia (pre-B-ALL) and here we further characterised their prevalence, survival outcomes and transcriptome. METHODS: Bone marrow mononuclear cells from 274 BCR-ABL1-negative pre-B-...

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Detalles Bibliográficos
Autores principales: McClure, Barbara J., Heatley, Susan L., Kok, Chung H, Sadras, Teresa, An, Jiyuan, Hughes, Timothy P., Lock, Richard B., Yeung, David, Sutton, Rosemary, White, Deborah L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931087/
https://www.ncbi.nlm.nih.gov/pubmed/29531323
http://dx.doi.org/10.1038/s41416-018-0022-0