Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study

Some cancer predisposing germline mutations cause overt birth defects and congenital anomalies. Others are clinically silent and can only be suspected by the presence of increased cancer incidence in family members. A new study shows that long-term monitoring of families may be needed to discover pr...

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Detalles Bibliográficos
Autores principales: Ravindranath, Yaddanapudi, Spector, Logan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931095/
https://www.ncbi.nlm.nih.gov/pubmed/29593336
http://dx.doi.org/10.1038/s41416-018-0059-0
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author Ravindranath, Yaddanapudi
Spector, Logan G
author_facet Ravindranath, Yaddanapudi
Spector, Logan G
author_sort Ravindranath, Yaddanapudi
collection PubMed
description Some cancer predisposing germline mutations cause overt birth defects and congenital anomalies. Others are clinically silent and can only be suspected by the presence of increased cancer incidence in family members. A new study shows that long-term monitoring of families may be needed to discover previously unsuspected underlying cancer predisposing mutations.
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spelling pubmed-59310952019-04-17 Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study Ravindranath, Yaddanapudi Spector, Logan G Br J Cancer Editorial Some cancer predisposing germline mutations cause overt birth defects and congenital anomalies. Others are clinically silent and can only be suspected by the presence of increased cancer incidence in family members. A new study shows that long-term monitoring of families may be needed to discover previously unsuspected underlying cancer predisposing mutations. Nature Publishing Group UK 2018-03-29 2018-04-17 /pmc/articles/PMC5931095/ /pubmed/29593336 http://dx.doi.org/10.1038/s41416-018-0059-0 Text en © Cancer Research UK 2018 https://creativecommons.org/licenses/by/4.0/This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International licence (CC BY 4.0).
spellingShingle Editorial
Ravindranath, Yaddanapudi
Spector, Logan G
Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title_full Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title_fullStr Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title_full_unstemmed Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title_short Germline mutations as potential causes of childhood solid tumours: comments on the Norwegian childhood cancer cohort study
title_sort germline mutations as potential causes of childhood solid tumours: comments on the norwegian childhood cancer cohort study
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931095/
https://www.ncbi.nlm.nih.gov/pubmed/29593336
http://dx.doi.org/10.1038/s41416-018-0059-0
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