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AKR1C enzymes sustain therapy resistance in paediatric T-ALL

BACKGROUND: Despite chemotherapy intensification, a subgroup of high-risk paediatric T-cell acute lymphoblastic leukemia (T-ALL) patients still experience treatment failure. In this context, we hypothesised that therapy resistance in T-ALL might involve aldo-keto reductase 1C (AKR1C) enzymes as prev...

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Detalles Bibliográficos
Autores principales:	Bortolozzi, Roberta, Bresolin, Silvia, Rampazzo, Elena, Paganin, Maddalena, Maule, Francesca, Mariotto, Elena, Boso, Daniele, Minuzzo, Sonia, Agnusdei, Valentina, Viola, Giampietro, te Kronnie, Geertruy, Cazzaniga, Giovanni, Basso, Giuseppe, Persano, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931104/ https://www.ncbi.nlm.nih.gov/pubmed/29515258 http://dx.doi.org/10.1038/s41416-018-0014-0

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