From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation

Multiple clinical studies have revealed a link between genomic instability and response to anti-PD-1/PD-L1 therapy in cancer management. A recent study has revealed an important role for the ATR/Chk1 DNA damage checkpoint in regulating PD-L1 expression, raising important clinical and translational q...

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Detalles Bibliográficos
Autores principales: Mouw, Kent W., Konstantinopoulos, Panagiotis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931110/
https://www.ncbi.nlm.nih.gov/pubmed/29531322
http://dx.doi.org/10.1038/s41416-018-0017-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931110/
https://www.ncbi.nlm.nih.gov/pubmed/29531322
http://dx.doi.org/10.1038/s41416-018-0017-x

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