Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation

We have developed a general peptide macrocyclization strategy that involves a facile and chemoselective methionine bis-alkylation/dealkylation process. This method provides a straightforward and easy approach to generate cyclic peptides with tolerances of all amino acids (including Cys), variable lo...

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Detalles Bibliográficos
Autores principales: Shi, Xiaodong, Zhao, Rongtong, Jiang, Yixiang, Zhao, Hui, Tian, Yuan, Jiang, Yanhong, Li, Jingxu, Qin, Weirong, Yin, Feng, Li, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931191/
https://www.ncbi.nlm.nih.gov/pubmed/29844896
http://dx.doi.org/10.1039/c7sc05109c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931191/
https://www.ncbi.nlm.nih.gov/pubmed/29844896
http://dx.doi.org/10.1039/c7sc05109c

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