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Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation
We have developed a general peptide macrocyclization strategy that involves a facile and chemoselective methionine bis-alkylation/dealkylation process. This method provides a straightforward and easy approach to generate cyclic peptides with tolerances of all amino acids (including Cys), variable lo...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931191/ https://www.ncbi.nlm.nih.gov/pubmed/29844896 http://dx.doi.org/10.1039/c7sc05109c |