Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation

Ciclopirox olamine (CPX), an off-patent anti-fungal drug, has been found to inhibit the G(1)-cyclin dependent kinases partly by increasing the phosphorylation and degradation of Cdc25A. However, little is known about the molecular target(s) of CPX responsible for Cdc25A degradation. Here, we show th...

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Detalles Bibliográficos
Autores principales: Shen, Tao, Zhou, Hongyu, Shang, Chaowei, Luo, Yan, Wu, Yang, Huang, Shile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931253/
https://www.ncbi.nlm.nih.gov/pubmed/29725502
http://dx.doi.org/10.18632/genesandcancer.166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931253/
https://www.ncbi.nlm.nih.gov/pubmed/29725502
http://dx.doi.org/10.18632/genesandcancer.166

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