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Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation

Ciclopirox olamine (CPX), an off-patent anti-fungal drug, has been found to inhibit the G(1)-cyclin dependent kinases partly by increasing the phosphorylation and degradation of Cdc25A. However, little is known about the molecular target(s) of CPX responsible for Cdc25A degradation. Here, we show th...

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Detalles Bibliográficos
Autores principales:	Shen, Tao, Zhou, Hongyu, Shang, Chaowei, Luo, Yan, Wu, Yang, Huang, Shile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931253/ https://www.ncbi.nlm.nih.gov/pubmed/29725502 http://dx.doi.org/10.18632/genesandcancer.166

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