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Recent advances in managing/understanding meningioma
Meningiomas are the most common adult primary intracranial tumor. Despite their higher incidence, there have not—until recently—been as many advances in understanding and managing meningiomas. Thus far, two broad classes of meningiomas have emerged on the basis of their mutational profile: those dri...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931261/ https://www.ncbi.nlm.nih.gov/pubmed/29770198 http://dx.doi.org/10.12688/f1000research.13674.1 |
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author | Shaikh, Nawal Dixit, Karan Raizer, Jeffrey |
author_facet | Shaikh, Nawal Dixit, Karan Raizer, Jeffrey |
author_sort | Shaikh, Nawal |
collection | PubMed |
description | Meningiomas are the most common adult primary intracranial tumor. Despite their higher incidence, there have not—until recently—been as many advances in understanding and managing meningiomas. Thus far, two broad classes of meningiomas have emerged on the basis of their mutational profile: those driven by neurofibromatosis 2 (NF2) inactivation and those with non-NF2 driver gene alterations, such as mammalian target of rapamycin and Hedgehog, Wingless/b-catenin, Notch, transforming growth factor-b receptor, mitogen-activated protein kinase, and phospholipase C pathway alterations. In addition to improvements in molecular diagnostics, advances in imaging are being studied to better predict tumor behavior, stratify risk, and potentially monitor for disease response. Management consists primarily of surgery and radiation therapy and there has been limited success from medical therapies, although novel targeted agents are now in clinical trials. Advances in imaging and understanding of the genetic makeup of meningiomas demonstrate the huge potential in revolutionizing the classification, diagnosis, management, and prognosis of meningiomas.. |
format | Online Article Text |
id | pubmed-5931261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-59312612018-05-15 Recent advances in managing/understanding meningioma Shaikh, Nawal Dixit, Karan Raizer, Jeffrey F1000Res Review Meningiomas are the most common adult primary intracranial tumor. Despite their higher incidence, there have not—until recently—been as many advances in understanding and managing meningiomas. Thus far, two broad classes of meningiomas have emerged on the basis of their mutational profile: those driven by neurofibromatosis 2 (NF2) inactivation and those with non-NF2 driver gene alterations, such as mammalian target of rapamycin and Hedgehog, Wingless/b-catenin, Notch, transforming growth factor-b receptor, mitogen-activated protein kinase, and phospholipase C pathway alterations. In addition to improvements in molecular diagnostics, advances in imaging are being studied to better predict tumor behavior, stratify risk, and potentially monitor for disease response. Management consists primarily of surgery and radiation therapy and there has been limited success from medical therapies, although novel targeted agents are now in clinical trials. Advances in imaging and understanding of the genetic makeup of meningiomas demonstrate the huge potential in revolutionizing the classification, diagnosis, management, and prognosis of meningiomas.. F1000 Research Limited 2018-04-24 /pmc/articles/PMC5931261/ /pubmed/29770198 http://dx.doi.org/10.12688/f1000research.13674.1 Text en Copyright: © 2018 Shaikh N et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Shaikh, Nawal Dixit, Karan Raizer, Jeffrey Recent advances in managing/understanding meningioma |
title | Recent advances in managing/understanding meningioma |
title_full | Recent advances in managing/understanding meningioma |
title_fullStr | Recent advances in managing/understanding meningioma |
title_full_unstemmed | Recent advances in managing/understanding meningioma |
title_short | Recent advances in managing/understanding meningioma |
title_sort | recent advances in managing/understanding meningioma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931261/ https://www.ncbi.nlm.nih.gov/pubmed/29770198 http://dx.doi.org/10.12688/f1000research.13674.1 |
work_keys_str_mv | AT shaikhnawal recentadvancesinmanagingunderstandingmeningioma AT dixitkaran recentadvancesinmanagingunderstandingmeningioma AT raizerjeffrey recentadvancesinmanagingunderstandingmeningioma |