IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE

Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c(hi)T-bet(+) B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is ex...

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Detalles Bibliográficos
Autores principales: Wang, Shu, Wang, Jingya, Kumar, Varsha, Karnell, Jodi L., Naiman, Brian, Gross, Phillip S., Rahman, Saifur, Zerrouki, Kamelia, Hanna, Richard, Morehouse, Christopher, Holoweckyj, Nicholas, Liu, Hao, Manna, Zerai, Goldbach-Mansky, Raphaela, Hasni, Sarfaraz, Siegel, Richard, Sanjuan, Miguel, Streicher, Katie, Cancro, Michael P., Kolbeck, Roland, Ettinger, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931508/
https://www.ncbi.nlm.nih.gov/pubmed/29717110
http://dx.doi.org/10.1038/s41467-018-03750-7

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