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Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells

Although ErbB2-targeted therapeutics have significantly improved ErbB2(+) breast cancer patient outcomes, therapeutic resistance remains a significant challenge. Therefore, the development of novel ErbB2-targeting strategies is necessary. Importantly, ErbB2 is a sensitive client protein of heat shoc...

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Detalles Bibliográficos
Autores principales:	Lee, Harry, Saini, Nipun, Howard, Erin W., Parris, Amanda B., Ma, Zhikun, Zhao, Qingxia, Zhao, Ming, Liu, Bolin, Edgerton, Susan M., Thor, Ann D., Yang, Xiaohe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931511/ https://www.ncbi.nlm.nih.gov/pubmed/29717218 http://dx.doi.org/10.1038/s41598-018-25284-0

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