Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the central metabolic sensor, AMPK, phosphorylates DA...

Descripción completa

Detalles Bibliográficos
Autores principales: Shiloh, Ruth, Gilad, Yuval, Ber, Yaara, Eisenstein, Miriam, Aweida, Dina, Bialik, Shani, Cohen, Shenhav, Kimchi, Adi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931534/
https://www.ncbi.nlm.nih.gov/pubmed/29717115
http://dx.doi.org/10.1038/s41467-018-03907-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931534/
https://www.ncbi.nlm.nih.gov/pubmed/29717115
http://dx.doi.org/10.1038/s41467-018-03907-4

Ejemplares similares