Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the central metabolic sensor, AMPK, phosphorylates DA...

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Detalles Bibliográficos
Autores principales: Shiloh, Ruth, Gilad, Yuval, Ber, Yaara, Eisenstein, Miriam, Aweida, Dina, Bialik, Shani, Cohen, Shenhav, Kimchi, Adi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931534/
https://www.ncbi.nlm.nih.gov/pubmed/29717115
http://dx.doi.org/10.1038/s41467-018-03907-4

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