Allosteric modulation of the farnesoid X receptor by a small molecule

The bile acid activated transcription factor farnesoid X receptor (FXR) regulates numerous metabolic processes and is a rising target for the treatment of hepatic and metabolic disorders. FXR agonists have revealed efficacy in treating non-alcoholic steatohepatitis (NASH), diabetes and dyslipidemia....

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Detalles Bibliográficos
Autores principales: Gabler, Matthias, Kramer, Jan, Schmidt, Jurema, Pollinger, Julius, Weber, Julia, Kaiser, Astrid, Löhr, Frank, Proschak, Ewgenij, Schubert-Zsilavecz, Manfred, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931576/
https://www.ncbi.nlm.nih.gov/pubmed/29717168
http://dx.doi.org/10.1038/s41598-018-25158-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931576/
https://www.ncbi.nlm.nih.gov/pubmed/29717168
http://dx.doi.org/10.1038/s41598-018-25158-5

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