Validating the concept of mutational signatures with isogenic cell models

The diversity of somatic mutations in human cancers can be decomposed into individual mutational signatures, patterns of mutagenesis that arise because of DNA damage and DNA repair processes that have occurred in cells as they evolved towards malignancy. Correlations between mutational signatures an...

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Detalles Bibliográficos
Autores principales: Zou, Xueqing, Owusu, Michel, Harris, Rebecca, Jackson, Stephen P., Loizou, Joanna I., Nik-Zainal, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931590/
https://www.ncbi.nlm.nih.gov/pubmed/29717121
http://dx.doi.org/10.1038/s41467-018-04052-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931590/
https://www.ncbi.nlm.nih.gov/pubmed/29717121
http://dx.doi.org/10.1038/s41467-018-04052-8

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