Exploiting glycan topography for computational design of Env glycoprotein antigenicity

Mounting evidence suggests that glycans, rather than merely serving as a “shield”, contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs). While many studies have focused on defining...

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Detalles Bibliográficos
Autores principales: Yu, Wen-Han, Zhao, Peng, Draghi, Monia, Arevalo, Claudia, Karsten, Christina B., Suscovich, Todd J., Gunn, Bronwyn, Streeck, Hendrik, Brass, Abraham L., Tiemeyer, Michael, Seaman, Michael, Mascola, John R., Wells, Lance, Lauffenburger, Douglas A., Alter, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931682/
https://www.ncbi.nlm.nih.gov/pubmed/29677181
http://dx.doi.org/10.1371/journal.pcbi.1006093

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