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Complement Activation in Patients With Diabetic Nephropathy
INTRODUCTION: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932121/ https://www.ncbi.nlm.nih.gov/pubmed/29725633 http://dx.doi.org/10.1016/j.ekir.2017.10.005 |
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author | Bus, Pascal Chua, Jamie S. Klessens, Céline Q.F. Zandbergen, Malu Wolterbeek, Ron van Kooten, Cees Trouw, Leendert A. Bruijn, Jan A. Baelde, Hans J. |
author_facet | Bus, Pascal Chua, Jamie S. Klessens, Céline Q.F. Zandbergen, Malu Wolterbeek, Ron van Kooten, Cees Trouw, Leendert A. Bruijn, Jan A. Baelde, Hans J. |
author_sort | Bus, Pascal |
collection | PubMed |
description | INTRODUCTION: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. METHODS: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease. The presence of complement deposits was scored by researchers who were blinded with respect to the clinical and histological data. RESULTS: C4d deposits were more prevalent in cases with DN than in cases without DN in both the glomeruli (46% vs. 26%) and the arterioles (28% vs. 12%). C1q deposits were also increased in the glomerular hili (77% vs. 55%) and arterioles (33% vs.14%), and were correlated with DN (P < 0.01). MBL deposits were only rarely observed. C5b-9 deposits were more prevalent in the cases with diabetes mellitus (DM) than in the cases without DM (69% vs. 32%; P < 0.001). Finally, glomerular C4d and C5b-9 deposits were correlated with the severity of DN (ρ = 0.341 and 0.259, respectively; P < 0.001). CONCLUSION: Complement activation is correlated with both the presence and severity of DN, suggesting that the complement system is involved in the development of renal pathology in patients with diabetes and is a promising target for inhibiting and/or preventing DN in these patients. |
format | Online Article Text |
id | pubmed-5932121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59321212018-05-03 Complement Activation in Patients With Diabetic Nephropathy Bus, Pascal Chua, Jamie S. Klessens, Céline Q.F. Zandbergen, Malu Wolterbeek, Ron van Kooten, Cees Trouw, Leendert A. Bruijn, Jan A. Baelde, Hans J. Kidney Int Rep Clinical Research INTRODUCTION: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. METHODS: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease. The presence of complement deposits was scored by researchers who were blinded with respect to the clinical and histological data. RESULTS: C4d deposits were more prevalent in cases with DN than in cases without DN in both the glomeruli (46% vs. 26%) and the arterioles (28% vs. 12%). C1q deposits were also increased in the glomerular hili (77% vs. 55%) and arterioles (33% vs.14%), and were correlated with DN (P < 0.01). MBL deposits were only rarely observed. C5b-9 deposits were more prevalent in the cases with diabetes mellitus (DM) than in the cases without DM (69% vs. 32%; P < 0.001). Finally, glomerular C4d and C5b-9 deposits were correlated with the severity of DN (ρ = 0.341 and 0.259, respectively; P < 0.001). CONCLUSION: Complement activation is correlated with both the presence and severity of DN, suggesting that the complement system is involved in the development of renal pathology in patients with diabetes and is a promising target for inhibiting and/or preventing DN in these patients. Elsevier 2017-10-16 /pmc/articles/PMC5932121/ /pubmed/29725633 http://dx.doi.org/10.1016/j.ekir.2017.10.005 Text en © 2017 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical Research Bus, Pascal Chua, Jamie S. Klessens, Céline Q.F. Zandbergen, Malu Wolterbeek, Ron van Kooten, Cees Trouw, Leendert A. Bruijn, Jan A. Baelde, Hans J. Complement Activation in Patients With Diabetic Nephropathy |
title | Complement Activation in Patients With Diabetic Nephropathy |
title_full | Complement Activation in Patients With Diabetic Nephropathy |
title_fullStr | Complement Activation in Patients With Diabetic Nephropathy |
title_full_unstemmed | Complement Activation in Patients With Diabetic Nephropathy |
title_short | Complement Activation in Patients With Diabetic Nephropathy |
title_sort | complement activation in patients with diabetic nephropathy |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932121/ https://www.ncbi.nlm.nih.gov/pubmed/29725633 http://dx.doi.org/10.1016/j.ekir.2017.10.005 |
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