Cargando…
Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
OBJECTIVES: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. MATERIALS AND METHODS:...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Oral and Maxillofacial Surgeons
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932274/ https://www.ncbi.nlm.nih.gov/pubmed/29732311 http://dx.doi.org/10.5125/jkaoms.2018.44.2.66 |
_version_ | 1783319780463214592 |
---|---|
author | Min, Seung-Ki Jeong, Joo Hee Ahn, Kang-Min Yoo, Chong Woo Park, Joo Yong Choi, Sung Weon |
author_facet | Min, Seung-Ki Jeong, Joo Hee Ahn, Kang-Min Yoo, Chong Woo Park, Joo Yong Choi, Sung Weon |
author_sort | Min, Seung-Ki |
collection | PubMed |
description | OBJECTIVES: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. MATERIALS AND METHODS: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. RESULTS: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. CONCLUSION: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival. |
format | Online Article Text |
id | pubmed-5932274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Association of Oral and Maxillofacial Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-59322742018-05-05 Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics Min, Seung-Ki Jeong, Joo Hee Ahn, Kang-Min Yoo, Chong Woo Park, Joo Yong Choi, Sung Weon J Korean Assoc Oral Maxillofac Surg Original Article OBJECTIVES: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. MATERIALS AND METHODS: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. RESULTS: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. CONCLUSION: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival. The Korean Association of Oral and Maxillofacial Surgeons 2018-04 2018-04-25 /pmc/articles/PMC5932274/ /pubmed/29732311 http://dx.doi.org/10.5125/jkaoms.2018.44.2.66 Text en Copyright © 2018 The Korean Association of Oral and Maxillofacial Surgeons. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Min, Seung-Ki Jeong, Joo Hee Ahn, Kang-Min Yoo, Chong Woo Park, Joo Yong Choi, Sung Weon Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title | Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title_full | Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title_fullStr | Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title_full_unstemmed | Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title_short | Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
title_sort | desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932274/ https://www.ncbi.nlm.nih.gov/pubmed/29732311 http://dx.doi.org/10.5125/jkaoms.2018.44.2.66 |
work_keys_str_mv | AT minseungki desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics AT jeongjoohee desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics AT ahnkangmin desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics AT yoochongwoo desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics AT parkjooyong desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics AT choisungweon desmoplasticmelanomaoftheoralcavitydiagnosticpitfallsandclinicalcharacteristics |