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Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infe...

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Detalles Bibliográficos
Autores principales: Łopata, Krzysztof, Wojdas, Emilia, Nowak, Roman, Łopata, Paweł, Mazurek, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932395/
https://www.ncbi.nlm.nih.gov/pubmed/29755422
http://dx.doi.org/10.3389/fmicb.2018.00730
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author Łopata, Krzysztof
Wojdas, Emilia
Nowak, Roman
Łopata, Paweł
Mazurek, Urszula
author_facet Łopata, Krzysztof
Wojdas, Emilia
Nowak, Roman
Łopata, Paweł
Mazurek, Urszula
author_sort Łopata, Krzysztof
collection PubMed
description The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk.
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spelling pubmed-59323952018-05-11 Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells Łopata, Krzysztof Wojdas, Emilia Nowak, Roman Łopata, Paweł Mazurek, Urszula Front Microbiol Microbiology The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk. Frontiers Media S.A. 2018-04-11 /pmc/articles/PMC5932395/ /pubmed/29755422 http://dx.doi.org/10.3389/fmicb.2018.00730 Text en Copyright © 2018 Łopata, Wojdas, Nowak, Łopata and Mazurek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Łopata, Krzysztof
Wojdas, Emilia
Nowak, Roman
Łopata, Paweł
Mazurek, Urszula
Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title_full Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title_fullStr Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title_full_unstemmed Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title_short Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
title_sort porcine endogenous retrovirus (perv) – molecular structure and replication strategy in the context of retroviral infection risk of human cells
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932395/
https://www.ncbi.nlm.nih.gov/pubmed/29755422
http://dx.doi.org/10.3389/fmicb.2018.00730
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