Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study

CYLD is a deubiquitinating enzyme that plays a crucial role in immunity and inflammation as a negative regulator of NF-κB transcription factor and JNK kinase signaling. Defects in either of these pathways contribute to the progression of numerous inflammatory and autoimmune disorders. Therefore, we...

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Detalles Bibliográficos
Autores principales: Lork, Marie, Kreike, Marja, Staal, Jens, Beyaert, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932415/
https://www.ncbi.nlm.nih.gov/pubmed/29755980
http://dx.doi.org/10.3389/fcell.2018.00040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932415/
https://www.ncbi.nlm.nih.gov/pubmed/29755980
http://dx.doi.org/10.3389/fcell.2018.00040

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