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17β-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia

17β-Estradiol (E2) is a well-known neuroprotective hormone, but its role in regulation of neuroinflammation is less understood. Recently, our lab demonstrated that E2 could regulate the NLRP3 (NOD-like receptor protein 3) inflammasome pathway in the hippocampus following global cerebral ischemia (GC...

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Detalles Bibliográficos
Autores principales: Thakkar, Roshni, Wang, Ruimin, Wang, Jing, Vadlamudi, Ratna K., Brann, Darrell W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932444/
https://www.ncbi.nlm.nih.gov/pubmed/29849895
http://dx.doi.org/10.1155/2018/4248526