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Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache
Cluster headache is a rare painful primary disorder occurring in either episodic or chronic patterns. Several authors found that the hypothalamus, the brain region regulating endocrine function and autonomic system, is involved in the pathophysiology of cluster headache. Some authors have found in p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932500/ https://www.ncbi.nlm.nih.gov/pubmed/29850313 http://dx.doi.org/10.1155/2018/3901619 |
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author | Antonio, Costantini Massimo, Tiberi Gianpaolo, Zarletti Immacolata, Pala Maria Erika, Trevi |
author_facet | Antonio, Costantini Massimo, Tiberi Gianpaolo, Zarletti Immacolata, Pala Maria Erika, Trevi |
author_sort | Antonio, Costantini |
collection | PubMed |
description | Cluster headache is a rare painful primary disorder occurring in either episodic or chronic patterns. Several authors found that the hypothalamus, the brain region regulating endocrine function and autonomic system, is involved in the pathophysiology of cluster headache. Some authors have found in patients affected by this disease abnormality in glucose metabolism. Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine. We report a 41-year-old man suffering from primary chronic cluster headache since the age of 15 years. The patient began oral therapy with high-dose thiamine in December 2016. Oral thiamine supplementation led to a dramatic improvement of the symptoms. The therapy was effective in reversing all the symptoms of the disease. Our observation suggests that a thiamine deficiency due to enzymatic abnormalities or to dysfunction of the circulation of thiamine in the intracellular space could cause a neuronal selective impairment in the centers that are involved in this disease and could have an important role in the pathogenesis of the symptoms of cluster headache. |
format | Online Article Text |
id | pubmed-5932500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59325002018-05-30 Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache Antonio, Costantini Massimo, Tiberi Gianpaolo, Zarletti Immacolata, Pala Maria Erika, Trevi Case Rep Neurol Med Case Report Cluster headache is a rare painful primary disorder occurring in either episodic or chronic patterns. Several authors found that the hypothalamus, the brain region regulating endocrine function and autonomic system, is involved in the pathophysiology of cluster headache. Some authors have found in patients affected by this disease abnormality in glucose metabolism. Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine. We report a 41-year-old man suffering from primary chronic cluster headache since the age of 15 years. The patient began oral therapy with high-dose thiamine in December 2016. Oral thiamine supplementation led to a dramatic improvement of the symptoms. The therapy was effective in reversing all the symptoms of the disease. Our observation suggests that a thiamine deficiency due to enzymatic abnormalities or to dysfunction of the circulation of thiamine in the intracellular space could cause a neuronal selective impairment in the centers that are involved in this disease and could have an important role in the pathogenesis of the symptoms of cluster headache. Hindawi 2018-04-18 /pmc/articles/PMC5932500/ /pubmed/29850313 http://dx.doi.org/10.1155/2018/3901619 Text en Copyright © 2018 Costantini Antonio et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Antonio, Costantini Massimo, Tiberi Gianpaolo, Zarletti Immacolata, Pala Maria Erika, Trevi Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title | Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title_full | Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title_fullStr | Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title_full_unstemmed | Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title_short | Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache |
title_sort | oral high-dose thiamine improves the symptoms of chronic cluster headache |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932500/ https://www.ncbi.nlm.nih.gov/pubmed/29850313 http://dx.doi.org/10.1155/2018/3901619 |
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