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Rapamycin Inhibits the Growth and Collagen Production of Fibroblasts Derived from Human Urethral Scar Tissue

Rapamycin can inhibit fibroblast proliferation, collagen accumulation, and urethral stricture in rabbits. Transforming growth factor-beta-1 (TGF-β1) signaling, with downstream recruitment of Smad2, is known to promote fibrosis. This in vitro study examined the effects of rapamycin on fibroblasts der...

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Detalles Bibliográficos
Autores principales:	Fu, Delai, Yin, Jian, Huang, Shanlong, Li, Hecheng, Li, Zhaolun, Chong, Tie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932518/ https://www.ncbi.nlm.nih.gov/pubmed/29850566 http://dx.doi.org/10.1155/2018/7851327

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