Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster

Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted Gnas cluster, the paternally expressed Nespas lncRNA downregulates its sense counterpart Nesp. To explore the mechanism of action of Nespas, we generated two new knock-in alleles...

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Detalles Bibliográficos
Autores principales: Tibbit, Charlotte J., Williamson, Christine M., Mehta, Stuti, Ball, Simon T., Chotalia, Mita, Nottingham, Wade T., Eaton, Sally A., Quwailid, Mohamed M., Teboul, Lydia, Kelsey, Gavin, Peters, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932550/
https://www.ncbi.nlm.nih.gov/pubmed/29861426
http://dx.doi.org/10.3390/ncrna1030246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932550/
https://www.ncbi.nlm.nih.gov/pubmed/29861426
http://dx.doi.org/10.3390/ncrna1030246

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