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A genetic modifier suggests that endurance exercise exacerbates Huntington's disease

Polyglutamine expansions in the huntingtin gene cause Huntington’s disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of t...

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Detalles Bibliográficos
Autores principales:	Corrochano, Silvia, Blanco, Gonzalo, Williams, Debbie, Wettstein, Jessica, Simon, Michelle, Kumar, Saumya, Moir, Lee, Agnew, Thomas, Stewart, Michelle, Landman, Allison, Kotiadis, Vassilios N, Duchen, Michael R, Wackerhage, Henning, Rubinsztein, David C, Brown, Steve D M, Acevedo-Arozena, Abraham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932560/ https://www.ncbi.nlm.nih.gov/pubmed/29509900 http://dx.doi.org/10.1093/hmg/ddy077

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