Identification of a selective DNA ligase for accurate recognition and ultrasensitive quantification of N(6)-methyladenosine in RNA at one-nucleotide resolution

N (6)-Methyladenosine (m(6)A) is the most frequent post-transcriptional modification in RNA, and it plays a critical role in biological processes. The functions of m(6)A remain largely unexplored due to a lack of highly sensitive methods to quantitatively determine the m(6)A modification fraction at...

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Detalles Bibliográficos
Autores principales: Liu, Weiliang, Yan, Jingli, Zhang, Zhenhao, Pian, Hongru, Liu, Chenghui, Li, Zhengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932600/
https://www.ncbi.nlm.nih.gov/pubmed/29780465
http://dx.doi.org/10.1039/c7sc05233b

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