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Outcome pre-specification requires sufficient detail to guard against outcome switching in clinical trials: a case study

BACKGROUND: Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most favourable result reported. METHODS: In orde...

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Detalles Bibliográficos
Autores principales:	Kahan, Brennan C., Jairath, Vipul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932799/ https://www.ncbi.nlm.nih.gov/pubmed/29720248 http://dx.doi.org/10.1186/s13063-018-2654-z

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