Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

BACKGROUND: Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implicated in inflammation-induced muscle atrophy. Since poly-Ub conjugation is requi...

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Detalles Bibliográficos
Autores principales: Ceelen, Judith J. M., Schols, Annemie M. W. J., Thielen, Nathalie G. M., Haegens, Astrid, Gray, Douglas A., Kelders, Marco C. J. M., de Theije, Chiel C., Langen, Ramon C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932886/
https://www.ncbi.nlm.nih.gov/pubmed/29720191
http://dx.doi.org/10.1186/s12931-018-0753-8

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